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Upon activation, the NLRP3 inflammasome recruits and activates downstream adaptor proteins, such as apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), which subsequently activates caspase-1
(2024) 403:e2131
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Future studies will further elucidate the currently unrecognized metabolic landscape of TLS
Caffeine: Caffeine is known to stimulate gastric emptying and may exacerbate gastrointestinal side effects associated with GLP-1 medications, such as nausea or diarrhea
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